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Verge of Parkinson’s Disease Breakthroughs

While there is no established cure for Parkinson’s disease, it became important for researchers to study and formulate therapies to treat and manage its symptoms. Research on Parkinson’s disease has made significant progress over the years. Scientists have been working to develop new *****, promoting a sigh of relief and real hope among people living with the disease. 

“Parkinson’s disease is the fastest-growing neurological disease that affects movement. It starts gradually in most people with a barely noticeable tremor in the hand. Most significantly, patients with Parkinson’s disease experience severe stiffness with slowing of movement.”

New Drug for Parkinson’s “off” time 

Istradefylline, an FDA-approved drug sold under the brand name Nourianz, is now available by prescription for Parkinson’s “off” time – that period of treatment when symptoms (including tremors and difficulty walking) of the disease reemerge periodically between the doses

Istradefylline is a receptor antagonist that can be prescribed as an add-on treatment to patients experiencing “off” episodes. Some long-term treatments can result in such reemerging abnormalities – where this regimen can reduce PD symptoms easily. 

Clinically, it is a selective adenosine A2A receptor antagonist developed by Kyowa Hakko Kirin in Japan. Nourianz effectively works by targeting adenosine A2A receptors in the basal ganglia. All in all, four clinical studies have demonstrated a notable decrease in “off” time PD symptoms. 

Your doctor might prescribe Nourianz only when you do not have a history of dyskinesia, psychotic behavior, liver dysfunction, and alcohol abuse. Regular tests during your treatment, however, will keep a check on the improvements. 

Lined-up Future Treatments

Thanks to the progress made by the researchers, we can now list a few treatments that could stand up front in the coming years. These therapies are being proven to possess the ability to manage and even reverse Parkinson’s disease. 

  1. Stem cell therapies 
  2. Gene therapies 
  3. Neural growth factor
  4. Deep brain stimulation
  5. Drug treatments

Clinical trials of such therapies give hope and assurance to patients suffering from Parkinson’s disease. You can even be a part of such trials and do your part. Ask your medical team!

Already-Existing Treatments 

More often, Parkinson’s disease is diagnosed at an advanced stage since there is no specifically established test for this neurological disorder. However, when diagnosed, the doctor prescribes medications to control or manage the symptoms. 

The following are some of the medications that can reduce the effects of symptoms fairly well. 

  1. Carbidopa-levodopa
  2. Inhaled carbidopa-levodopa
  3. Carbidopa-levodopa infusion
  4. Dopamine agonists
  5. MAO B inhibitors
  6. Catechol O-methyltransferase (COMT) inhibitor
  7. Anticholinergics
  8. Amantadine

In some severe cases, surgery may be recommended. Other than these regimens, surgical procedures can evidently help in diminishing the effects of the disease on the body. At present, three surgical approaches to treat Parkinson’s disease are known to us including Ablative Surgery (pallidotomy, thalamotomy), Deep Brain Stimulation (DBS), and Foetal Cell Transplantation.

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